About GIVE MOVE
The project in brief
Scanning of plasma samples for viral load testing in Butha-Buthe, Lesotho.
Antiretroviral therapy is life-saving for people living with HIV. However, children and adolescents with HIV in resource-limited settings have high rates of treatment failure, largely caused by poor adherence to medication or viral drug resistance. Genotypic drug resistance testing, a reliable but relatively costly and complex diagnostic tool to detect viral drug resistance, is routinely used in high-income settings but access is extremely limited in most areas that have the highest burden of HIV. This research project will assess if routine, early resistance testing yields a clinical benefit for children and adolescents with HIV viraemia in resource-limited settings in Southern and East Africa (Lesotho and Tanzania).
The study sites
GIVE MOVE project countries and sites.
GIVE MOVE is conducted at ten primary healthcare facilities in in Lesotho and Tanzania. Lesotho and Tanzania have an adult prevelance of HIV of 23.6% (the second-highest worldwide) and 4.6%, respectively (UNAIDS data 2019), with 21,000 children and adolescents with HIV in Lesotho and 150,000 in Tanzania (UNICEF 2019).
In Lesotho, the study is conducted at six facilities in five districts: the Baylor College of Medicine Children’s Foundation Lesotho Centre of Excellence in Maseru, Baylor Satellite Centres of Excellence in Mohale’s Hoek, Hlotse, Butha-Buthe, and Mokhotlong, and Seboche Mission Hospital.
In Tanzania, GIVE MOVE is conducted at the One-Stop Clinic of the Chronic Diseases Clinic Ifakara at St Francis Referral Hospital in Ifakara, and at three sites supported by Management and Development for Health in Dar es Salaam, namely Upendano Dispensary, Mbagala Rangi Tatu hospital, and Temeke Regional Referral Hospital.
Consenting procedure in Lesotho
One-Stop Clinic in Ifakara, Tanzania
